{"id":20600,"date":"2024-04-05T16:10:12","date_gmt":"2024-04-05T14:10:12","guid":{"rendered":"https:\/\/bmscience.net\/blog\/?p=20600"},"modified":"2024-04-05T16:13:38","modified_gmt":"2024-04-05T14:13:38","slug":"lanemia-sideroblastica-clinica-diagnosi-e-trattamento","status":"publish","type":"post","link":"https:\/\/bmscience.net\/blog\/lanemia-sideroblastica-clinica-diagnosi-e-trattamento\/","title":{"rendered":"L&#8217;anemia sideroblastica &#8211; clinica, diagnosi e trattamento"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a36bc163e18e&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a36bc163e18e\" class=\"alignright size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1003\" height=\"618\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Sideroblasto-ad-anello.png\" alt=\"\" class=\"wp-image-20601\" style=\"width:292px;height:auto\" srcset=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Sideroblasto-ad-anello.png 1003w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Sideroblasto-ad-anello-300x185.png 300w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Sideroblasto-ad-anello-768x473.png 768w\" sizes=\"auto, (max-width: 1003px) 100vw, 1003px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Ingrandisci\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Sideroblasto ad anello<\/figcaption><\/figure>\n<\/div>\n\n\n<p>L&#8217;anemia sideroblastica \u00e8 una condizione caratterizzata dall&#8217;alterazione della sintesi del gruppo eme, con accumulo di ferro in eccesso all&#8217;interno dei mitocondri, formando cos\u00ec i <strong>sideroblasti ad anello<\/strong>. Questi sono eritroblasti con deposito di ferro intorno al nucleo. La condizione \u00e8 associata a:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Eritropoiesi inefficace:<\/strong> si verifica una distruzione intramidollare dei precursori eritropoietici, contribuendo all&#8217;inefficacia dell&#8217;eritropoiesi;<\/li>\n\n\n\n<li><strong>Aumento dei sideroblasti ad anello nel Midollo Osseo:<\/strong> questi sideroblasti ad anello, con il loro caratteristico accumulo di ferro, sono presenti in numero aumentato nel midollo osseo;<\/li>\n\n\n\n<li><strong>Aumento del ferro nei depositi tessutali:<\/strong> l&#8217;eccesso di ferro viene depositato nei tessuti, contribuendo al sovraccarico di ferro.<\/li>\n<\/ul>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor:pointer\">Indice<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #222222;color:#222222\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #222222;color:#222222\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/bmscience.net\/blog\/lanemia-sideroblastica-clinica-diagnosi-e-trattamento\/#Eziologia\" >Eziologia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/bmscience.net\/blog\/lanemia-sideroblastica-clinica-diagnosi-e-trattamento\/#Segni_clinici\" >Segni clinici<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/bmscience.net\/blog\/lanemia-sideroblastica-clinica-diagnosi-e-trattamento\/#Diagnosi\" >Diagnosi<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/bmscience.net\/blog\/lanemia-sideroblastica-clinica-diagnosi-e-trattamento\/#Trattamento\" >Trattamento<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Eziologia\"><\/span>Eziologia<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ereditaria:<\/strong> questa forma \u00e8 eccezionale ed \u00e8 solitamente legata al cromosoma X;<\/li>\n\n\n\n<li><strong>Acquisite:<\/strong>  sono le pi\u00f9 comuni e possono essere divise in primarie e secondarie:\n<ul class=\"wp-block-list\">\n<li><strong>Primarie:<\/strong> la forma pi\u00f9 frequente \u00e8 l&#8217;anemia refrattaria con sideroblasti ad anello, che \u00e8 un sottotipo di sindrome mielodisplastica;<\/li>\n\n\n\n<li><strong>Secondarie:<\/strong> queste possono essere causate da sostanze chimiche come il piombo e l&#8217;alcol, farmaci come l&#8217;isoniazide, la pirazinamide, il cloramfenicolo, carenza di vitamina B6 (piridossina), ecc. In queste condizioni, di solito si osservano sideroblasti ad anello, con o senza anemia associata.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div id=\"bmscience11539439\" style=\"margin-top: 15px;margin-bottom: 15px;margin-left: auto;margin-right: auto;text-align: center;\"><div data-id='24174' class='amazon-auto-links aal-js-loading'><p class='now-loading-placeholder'>Caricamento&#8230;.<\/p><\/div><\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Segni_clinici\"><\/span>Segni clinici<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Sindrome anemica:<\/strong> si manifesta in forme da moderate a gravi;<\/li>\n\n\n\n<li><strong>Deposito di ferro nei tessuti <\/strong>o<strong> emosiderosi:<\/strong> pu\u00f2 portare a complicazioni come diabete, insufficienza cardiaca e epatopatia;<\/li>\n\n\n\n<li><strong>Epatosplenomegalia:<\/strong> non sempre presente.<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6a36bc1650518&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6a36bc1650518\" class=\"alignright size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"535\" height=\"244\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Punteggiatura-basofila-nellintossicazione-da-piombo.png\" alt=\"\" class=\"wp-image-20602\" style=\"width:340px;height:auto\" srcset=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Punteggiatura-basofila-nellintossicazione-da-piombo.png 535w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/04\/Punteggiatura-basofila-nellintossicazione-da-piombo-300x137.png 300w\" sizes=\"auto, (max-width: 535px) 100vw, 535px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Ingrandisci\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\">Punteggiatura basofila nell&#8217;intossicazione da piombo<\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Diagnosi\"><\/span>Diagnosi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Emocromo:<\/strong> si osserva un&#8217;anemia microcitica nelle anemie sideroblastiche ereditarie e nelle anemie sideroblastiche acquisite secondarie a saturnismo (intossicazione da piombo); le anemie sideroblastiche acquisite primarie possono essere macro- o normocitiche;<\/li>\n\n\n\n<li><strong>Metabolismo del ferro:<\/strong> si riscontrano aumenti di ferro, saturazione della transferrina e ferritina;<\/li>\n\n\n\n<li><strong>Eritropoiesi inefficace:<\/strong> Livelli discreti di bilirubina e LDH, diminuzione dell&#8217;aptoglobina;<\/li>\n\n\n\n<li><strong>Midollo osseo:<\/strong> Presenza di sideroblasti ad anello e aumento del ferro macrofagico.<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><a href=\"https:\/\/amzn.to\/3G3UE4K\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"602\" height=\"853\" src=\"https:\/\/www.bmscience.net\/blog\/wp-content\/uploads\/2024\/01\/51eg3Zn5GL.jpg\" alt=\"\" class=\"wp-image-24121\" style=\"width:147px;height:auto\" srcset=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/01\/51eg3Zn5GL.jpg 602w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2024\/01\/51eg3Zn5GL-212x300.jpg 212w\" sizes=\"auto, (max-width: 602px) 100vw, 602px\" \/><\/a><figcaption class=\"wp-element-caption\"><strong><a href=\"https:\/\/amzn.to\/3O1N8s4\" target=\"_blank\" rel=\"noreferrer noopener\">Acquista ora<\/a><\/strong><\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Trattamento\"><\/span>Trattamento<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Se anemia:<\/strong> si utilizza vitamina B6 (piridossina), eventualmente associata ad acido folico per la carenza dovuta all&#8217;iperplasia della serie rossa, e trasfusioni nelle anemie gravi che non rispondono alla piridossina;<\/li>\n\n\n\n<li><strong>Se emosiderosi accertata:<\/strong> si utilizzano chelanti del ferro (deferoxamina) o flebotomie;<\/li>\n\n\n\n<li><strong>Anemia sideroblastica congenita grave:<\/strong> pu\u00f2 richiedere il trapianto allogenico di cellule staminali ematopoietiche.<\/li>\n<\/ul>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Fonte: <a href=\"https:\/\/amzn.to\/3O1N8s4\" target=\"_blank\" rel=\"noreferrer noopener\">Manuale di ematologia. Concorso Nazionale SSM.<\/a><\/p>\n<\/blockquote>\n\n\n<div id=\"bmscience3163419317\" style=\"margin-top: 15px;margin-bottom: 15px;margin-left: auto;margin-right: auto;text-align: center;\"><a href=\"https:\/\/amzn.to\/3YYbWWZ\" target=\"_blank\" aria-label=\"Italian_Header_Banner_-_John._CB1751449782_\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2026\/01\/Italian_Header_Banner_-_John._CB1751449782_.png\" alt=\"\"  srcset=\"https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2026\/01\/Italian_Header_Banner_-_John._CB1751449782_.png 1782w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2026\/01\/Italian_Header_Banner_-_John._CB1751449782_-300x41.png 300w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2026\/01\/Italian_Header_Banner_-_John._CB1751449782_-1024x139.png 1024w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2026\/01\/Italian_Header_Banner_-_John._CB1751449782_-768x104.png 768w, https:\/\/bmscience.net\/blog\/wp-content\/uploads\/2026\/01\/Italian_Header_Banner_-_John._CB1751449782_-1536x209.png 1536w\" sizes=\"auto, (max-width: 1782px) 100vw, 1782px\" width=\"1782\" height=\"242\"  style=\"display: inline-block;\" \/><\/a><\/div>","protected":false},"excerpt":{"rendered":"<p>L&#8217;anemia sideroblastica \u00e8 una condizione caratterizzata dall&#8217;alterazione della sintesi del gruppo eme, con accumulo di ferro in eccesso all&#8217;interno dei mitocondri, formando cos\u00ec i sideroblasti ad anello. Questi sono eritroblasti con deposito di ferro intorno al nucleo. La condizione \u00e8 associata a: Eziologia Segni clinici Diagnosi Trattamento<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[56],"tags":[505,8375,8380,8378,2815,8377,8379,8376,6809],"class_list":["post-20600","post","type-post","status-publish","format-standard","hentry","category-ematologia","tag-anemia","tag-anemia-sideroblastica","tag-deferoxamina","tag-emosiderosi","tag-epatosplenomegalia","tag-eritropoiesi-inefficace","tag-piridossina","tag-sideroblasti-ad-anello","tag-sindrome-anemica","entry"],"author_meta":{"display_name":"Raffo Coco","author_link":"https:\/\/bmscience.net\/blog\/author\/raffo\/"},"featured_img":null,"coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">Ematologia<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Ematologia<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">Anemia<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">anemia sideroblastica<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">deferoxamina<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">emosiderosi<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">epatosplenomegalia<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">Eritropoiesi Inefficace<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">piridossina<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">sideroblasti ad anello<\/a>","<a href=\"https:\/\/bmscience.net\/blog\/category\/medicina\/ematologia\/\" class=\"advgb-post-tax-term\">Sindrome anemica<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Anemia<\/span>","<span class=\"advgb-post-tax-term\">anemia sideroblastica<\/span>","<span class=\"advgb-post-tax-term\">deferoxamina<\/span>","<span class=\"advgb-post-tax-term\">emosiderosi<\/span>","<span class=\"advgb-post-tax-term\">epatosplenomegalia<\/span>","<span class=\"advgb-post-tax-term\">Eritropoiesi Inefficace<\/span>","<span class=\"advgb-post-tax-term\">piridossina<\/span>","<span class=\"advgb-post-tax-term\">sideroblasti ad anello<\/span>","<span class=\"advgb-post-tax-term\">Sindrome anemica<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Pubblicato 2 anni fa","modified":"Aggiornato 2 anni fa"},"absolute_dates":{"created":"Pubblicato il 05\/04\/2024","modified":"Aggiornato il 05\/04\/2024"},"absolute_dates_time":{"created":"Pubblicato il 05\/04\/2024 16:10","modified":"Aggiornato il 05\/04\/2024 16:13"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/posts\/20600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/comments?post=20600"}],"version-history":[{"count":0,"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/posts\/20600\/revisions"}],"wp:attachment":[{"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/media?parent=20600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/categories?post=20600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bmscience.net\/blog\/wp-json\/wp\/v2\/tags?post=20600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}